Publications

2024

1. Musundi SD, Gitaka J, Kanoi BN*. Identification of conserved cross-species B-cell linear epitopes in human malaria: A subtractive proteomics and immuno-informatics approach targeting merozoite stage proteins. Frontiers in Immunology. 2024 Feb 9;15:1352618. https://doi.org/10.3389/fimmu.2024.1352618

1. Hagadorn KA, Peterson,ME, Kole H, Scott B, Skinner J, Takashima E, Diouf A, Ongoiba A, Doumbo S, Doumtabe D, Li S, Sekar P, Yan M, Zhu C, Nagaoka H, Kanoi BN, Li Q, Long C, Long EO, Kayentao K, Jenks SA, Sanz I, Tsuboi T, Traore B, Bolland S, Miura K, Crompton P, Peter D, Hopp CS., Autoantibodies Inhibit Plasmodium falciparum Growth and Associate with Protection from Clinical Malaria. Immunity. 2024 (In Press) http://dx.doi.org/10.2139/ssrn.4621560

1. Kanoi BN*, Waweru H, Kobia FM, Mukala J, Kirira P, Mogere D, Gallini R, Aberg M, Vatish M, Gitaka J, Kamali-Moghaddam M. Differential expression of plasma proteins in pregnant women exposed to Plasmodium falciparum malaria. medRxiv. 2024:2024-05. https://doi.org/10.1101/2024.05.01.24306614

1. Chenge S, Mbalitsi M, Ngure H, Obimbo M, Singoei M, Kangogo M, Kanoi BN, Gitaka J, Kobia FM. Placental malaria is associated with a TLR-Endothelin-3-oxidative damage response in human placenta tissues. bioRxiv. 2024:2024-04. https://doi.org/10.1101/2024.04.17.589949

1. Mukala J, Mogere D, Kirira P, Kanoi BN, Akinyi V, Kobia F, Waweru H, Gitaka J. Knowledge, attitude and practices on intermittent preventive treatment in pregnant women with malaria: a mixed method facility-based study in Western Kenya. Pan African Medical Journal. 2024;48:22. [doi: 10.11604/pamj.2024.48.22.42196]

1. Maina M, Musundi SD, Kuja J, Waweru H, Kiboi J, Kanoi BN, and Gitaka J. Genetic Variation of the Plasmodium falciparum Circumsporozoite Protein in Parasite Isolates from Homabay County in Kenya. Front. Parasitol. Sec. Parasite Genetics Volume 3 - 2024 | doi: 10.3389/fpara.2024.1346017

1. Ko YK, Kagaya W, Omondi P, Musyoka KB, Okai T, Chan CW, Kongere J, Opiyo V, Oginga J, Mbugua S, Kanoi BN, Kanamori M, Yoneoka D, Kenya National Bureau of Statistics (KNBS), Keitany K, Songok E, Okomo G, Minakawa N, Gitaka J, Kaneko A. Evaluation of the protective efficacy of OlysetPlus ceiling nets for reduction of malaria incidence in children in Homa Bay County, Kenya: a cluster-randomized controlled study protocol. medRxiv. 2024:2024-04. doi: https://doi.org/10.1101/2024.04.20.24306116

1. Ko YK, Kagaya W, Chan CW, Kanamori M, Mbugua SM, Rotich AK, Kanoi BN, Ngara M, Gitaka J, Kaneko A. Unraveling the “indirect effects” of interventions against malaria endemicity: A systematic scoping review. medRxiv. 2024 May 8:2024-05. https://doi.org/10.1101/2024.05.08.24307059

1. Omondi P, Musyoka B, Okai T, Kongere J, Kagaya W, Chan C, Ngara M, Kanoi B, Kido Y, Gitaka J, Kaneko A. Non-Random Distribution of Plasmodium Species Infections and Associated Clinical Features in Children in The Lake Victoria Region, Kenya, 2012-2018. https://doi.org/10.21203/rs.3.rs-4454878/v1

1. Ally O, Kanoi BN, Kamath S, Shiluli C, Ndombi EM, Odiere M, Nyanjom SG, Misinzo G, Raju SL, Ochola L, Gitaka J. Development of a Rapid and Highly Sensitive Nucleic Acid-Based Diagnostic Test for Schistosomes, leveraging on Identical Multi-Repeat Sequences (IMRS). Frontiers in Parasitology. 2024 ;3:1361493. doi:10.3389/fpara.2024.1361493

1. Shiluli C, Kamath S, Kanoi BN, Kimani R, Maina M, Waweru H, Kamita M, Ndirangu I, Abkallo HM, Oduor B, Pamme N, Dupaty J, Klapperich CM, Lolabattu SR, Gitaka J. 2023. Improving Gonorrhoea Molecular Diagnostics: Genome Mining-Based Identification of Identical Multi-Repeat Sequences (IMRS) in Neisseria gonorrhoeae Genome. Heliyon, 2024, e27344,ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e27344
2. Mukala J, Mogere D, Kirira P, Kanoi BN, Akinyi V, Kobia FM, Waweru H, Gitaka J.. Predictors of birth weight in pregnant women with malaria: a prospective cohort facility-based study in Webuye-Kenya. BMC Pregnancy Childbirth 24, 187 (2024). https://doi.org/10.1186/s12884-024-06355-9

1. Kimani R, Wakaba P, Kamita M, Mbogo D, Mutai W, Ayodo C, Suliman E, Kanoi BN, Gitaka J. Detection of multidrug-resistant organisms of concern including Stenotrophomonas maltophilia and Burkholderia cepacia at a referral hospital in Kenya. Plos one. 2024 Apr 16;19(4):e0298873.

1. Musundi S, Nganga S, Wanjiru E, Sagoe K, Wandera E, Kanoi BN, Gitaka J Metatranscriptomic analysis of wastewater sites reveals a high abundance of antimicrobial resistance genes from hospital wastewater medRxiv 2024. 02.03.24302270; doi: https://doi.org/10.1101/2024.02.03.24302270 (preprint)

2023 and Before

1. Kimani R, Musundi S, Wakaba P, Mbogo D, Essuman S, Kanoi BN, Gitaka J.Application of nanopore sequencing to identify antimicrobial resistance genes, mobile genetic elements and virulence factors in clinical isolates. bioRxiv 2023. 10.25.563907; doi: https://doi.org/10.1101/2023.10.25.563907

1. Shiluli C, Kamath S, Kanoi BN, Kimani R, Maina M, Waweru H, Kamita M, Ndirangu I, Abkallo HM, Oduor B, Pamme N, Dupaty J, Klapperich CM, Lolabattu SR, Gitaka J. 2023. Identification of Multi-repeat Sequences using Genome Mining Approaches for Developing Highly Sensitive Molecular Diagnostic Assay for the Detection of Chlamydia trachomatis. [version 1; peer review: 1 approved, 1 approved with reservations]. Open Res Africa 2024, 7:2 (https://doi.org/10.12688/openresafrica.14316.1)

1. Mgawe C, Likhovole C, Ger S, Odari E, Linnes JC, Kanoi BN, Gitaka J, Ochola L. Application of multiple binding sites for LAMP primers across P. falciparum genome improves detection of the parasite from whole blood samples. Frontiers in Malaria. 2023;1:1303980

1. Chenge S, Ngure H, Kanoi BN, Sferruzzi-Perri AN, Kobia FM. Infectious and environmental placental insults: from underlying biological pathways to diagnostics and treatments. Pathogens and Disease (2023).

1. Hassan I, Kanoi BN, Nagaoka H, Sattabongkot J, Udomsangpetch R, Tsuboi T, Takashima E. High-Throughput Antibody Profiling Identifies Targets of Protective Immunity against P. falciparum Malaria in Thailand. Biomolecules. 2023; 13(8):1267. https://pubmed.ncbi.nlm.nih.gov/37627332/

1. Kagaya W, Chan CW, Kongere J, Kanoi BN, Ngara M, Omondi P, Osborne A, Barbieri L, Kc A, Minakawa N, Gitaka J. Evaluation of the protective efficacy of Olyset® Plus ceiling net on reducing malaria prevalence in children in Lake Victoria Basin, Kenya: study protocol for a cluster-randomized controlled trial. Trials. 2023 May 25;24(1):354. https://pubmed.ncbi.nlm.nih.gov/37231429/

1. Sagoe KO, Kyama MC, Maina N, Kamita M, Njokah M, Thiong’o K, Kanoi BN, Wandera EA, Ndegwa D, Kinyua DM, Gitaka J. 2023. Application of Hybridization Chain Reaction/CRISPR-Cas12a for the Detection of SARS-CoV-2 Infection. Diagnostics 13: 1644. https://pubmed.ncbi.nlm.nih.gov/37175035/

1. Waweru H, Kanoi BN, Kuja J, Maranga M, Kongere J, Maina M, Kinyua J, Gitaka J. Limited genetic variations of the Rh5-CyRPA-Ripr invasion complex in Plasmodium falciparum parasite population in selected malaria-endemic regions, Kenya. Frontiers in Tropical Diseases. 2023;4:18. https://www.frontiersin.org/articles/10.3389/fitd.2023.1102265/full

1. Mazhari R, Takashima E, Longley RJ, Ruybal-Pesantez S, White MT, Kanoi BN, Nagaoka H, Kiniboro B, Siba P, Tsuboi T, Mueller I. Identification of novel Plasmodium vivax proteins associated with protection against clinical malaria. Front Cell Infect Microbiol. 2023 Jan 25;13:28.. https://pubmed.ncbi.nlm.nih.gov/36761894/

1. Arisue N, Palacpac NM, Ntege EH, Yeka A, Balikagala B, Kanoi BN, Bougouma EC, Tiono AB, Nebie I, Diarra A, Houard S. African-specific polymorphisms in Plasmodium falciparum serine repeat antigen 5 in Uganda and Burkina Faso clinical samples do not interfere with antibody response to BK-SE36 vaccination. Front Cell Infect Microbiol. 2022 Dec 16;12:1817.

1. Baptista S, Naidoo S, Suliman S, Nepolo E, Kanoi BN, Gitaka J, Mbaebie Blessing O, Enany S. COVID-19 vaccinology landscape in Africa. Frontiers in Immunology. 2022;:7424.

1. Rotich AK, Takashima E, Yanow SK, Gitaka J, Kanoi BN*. Towards identification and development of alternative vaccines against pregnancy-associated malaria based on naturally acquired immunity. Front. Trop. Dis. 2022; 3:988284. doi: 10.3389/fitd.2022.988284

1. Kanoi BN*, Maina M, Likhovole C, Kobia FM and Gitaka J. Malaria vaccine approaches leveraging technologies optimized in the COVID-19 era. Front. Trop. Dis. 2022; 3:988665. doi: 10.3389/fitd.2022.988665

1. Takashima E, Kanoi BN, Nagaoka H, Morita M, Hassan I, Palacpac NMQ, et al. Meta-Analysis of Human Antibodies Against Plasmodium falciparum Variable Surface and Merozoite Stage Antigens. Front Immunol. 2022;13:887219; doi: 10.3389/fimmu.2022.887219. https://www.ncbi.nlm.nih.gov/pubmed/35757771

1. Kuja JO, Kanoi BN, Shiluli C, Maina M, Waweru H, Gethii K, et al. Genomic Surveillance of SARS-COV-2 reveals diverse circulating variant lineages in Nairobi and Kiambu County, Kenya. 2022. https://europepmc.org/article/ppr/ppr491829

1. Morita M, Kanoi BN, Shinzawa N, Kubota R, Takeda H, Sawasaki T, et al. AGIA Tag System for Ultrastructural Protein Localization Analysis in Blood-Stage Plasmodium falciparum. Front Cell Infect Microbiol. 2021;11:777291; doi: 10.3389/fcimb.2021.777291. https://www.ncbi.nlm.nih.gov/pubmed/34976861.

1. Takashima E, Tachibana M, Morita M, Nagaoka H, Kanoi BN, Tsuboi T. Identification of Novel Malaria Transmission-Blocking Vaccine Candidates. Front Cell Infect Microbiol. 2021;11:805482; doi: 10.3389/fcimb.2021.805482. https://www.ncbi.nlm.nih.gov/pubmed/34917521.

1. Kanoi BN*, Egwang TG. Sex differences in concentrations of HMGB1 and numbers of pigmented monocytes in infants and young children with malaria. Parasitol Int. 2021;84:102387; doi: 10.1016/j.parint.2021.102387. https://www.ncbi.nlm.nih.gov/pubmed/34022424.

1. Yuguchi T, Kanoi BN, Nagaoka H, Miura T, Ito D, Takeda H, et al. Plasmodium yoelii Erythrocyte Binding Like Protein Interacts With Basigin, an Erythrocyte Surface Protein. Front Cell Infect Microbiol. 2021;11:656620; doi: 10.3389/fcimb.2021.656620. https://www.ncbi.nlm.nih.gov/pubmed/33937099.

1. Nagaoka H, Kanoi BN, Morita M, Nakata T, Palacpac NMQ, Egwang TG, et al. Characterization of a Plasmodium falciparum PHISTc protein, PF3D7_0801000, in blood- stage malaria parasites. Parasitol Int. 2021;80:102240; doi: 10.1016/j.parint.2020.102240. https://www.ncbi.nlm.nih.gov/pubmed/33147497.

1. Kanoi BN, Nagaoka H, Morita M, Tsuboi T, Takashima E. Leveraging the wheat germ cell-free protein synthesis system to accelerate malaria vaccine development. Parasitol Int. 2021;80:102224; doi: 10.1016/j.parint.2020.102224. https://www.ncbi.nlm.nih.gov/pubmed/33137499.

1. Kanoi BN, Nagaoka H, White MT, Morita M, Palacpac NMQ, Ntege EH, et al. Global Repertoire of Human Antibodies Against Plasmodium falciparum RIFINs, SURFINs, and STEVORs in a Malaria Exposed Population. Front Immunol. 2020;11:893; doi: 10.3389/fimmu.2020. 00893. https://www.ncbi.nlm.nih.gov/pubmed/32477363.

1. Nagaoka H, Kanoi BN, Ntege EH, Aoki M, Fukushima A, Tsuboi T, et al. Antibodies against a short region of PfRipr inhibit Plasmodium falciparum merozoite invasion and PfRipr interaction with Rh5 and SEMA7A. Sci Rep. 2020;10 1:6573; doi: 10.1038/s41598-020-63611-6. https://www.ncbi.nlm.nih.gov/pubmed/32313230.

1. Nagaoka H, Kanoi BN, Jinoka K, Morita M, Arumugam TU, Palacpac NMQ, et al. The N-Terminal Region of Plasmodium falciparum MSP10 Is a Target of Protective Antibodies in Malaria and Is Important for PfGAMA/PfMSP10 Interaction. Front Immunol. 2019;10:2669; doi: 10.3389/fimmu.2019.02669. https://www.ncbi.nlm.nih.gov/pubmed/31824483.

1. Miura K, Tachibana M, Takashima E, Morita M, Kanoi BN, Nagaoka H, et al. Malaria transmission-blocking vaccines: wheat germ cell-free technology can accelerate vaccine development. Expert Rev Vaccines. 2019;18 10:1017-27; doi: 10.1080/14760584.2019.1674145. https://www.ncbi.nlm.nih.gov/pubmed/31566026.

1. Nagaoka H, Sasaoka C, Yuguchi T, Kanoi BN, Ito D, Morita M, et al. PfMSA180 is a novel Plasmodium falciparum vaccine antigen that interacts with human erythrocyte integrin associated protein (CD47). Sci Rep. 2019;9 1:5923; doi: 10.1038/s41598-019-42366-9. https://www.ncbi.nlm.nih.gov/pubmed/30976034.

1. Subissi L, Kanoi BN, Balikagala B, Egwang TG, Oguike M, Verra F, et al. Plasmodium malariae and Plasmodium ovale infections and their association with common red blood cell polymorphisms in a highly endemic area of Uganda. Transactions of the Royal Society of Tropical Medicine and Hygiene. 2019;113 7:370-8; doi: 10.1093/trstmh/trz015. https://www.ncbi.nlm.nih.gov/pubmed/30953444.

1. Kanoi BN, Nagaoka H, Morita M, White MT, Palacpac NMQ, Ntege EH, et al. Comprehensive analysis of antibody responses to Plasmodium falciparum erythrocyte membrane protein 1 domains. Vaccine. 2018;36 45:6826-33; doi: 10.1016/j.vaccine.2018.08.058. https://www.ncbi.nlm.nih.gov/pubmed/30262245.

1. Morita M, Nagaoka H, Ntege EH, Kanoi BN, Ito D, Nakata T, et al. PV1, a novel Plasmodium falciparum merozoite dense granule protein, interacts with exported protein in infected erythrocytes. Sci Rep. 2018;8 1:3696; doi: 10.1038/s41598-018-22026-0. https://www.ncbi.nlm.nih.gov/pubmed/29487358.

1. Sakamoto H, Takeo S, Takashima E, Miura K, Kanoi BN, Kaneko T, et al. Identification of target proteins of clinical immunity to Plasmodium falciparum in a region of low malaria transmission. Parasitol Int. 2018;67 2:203-8; doi: 10.1016/j.parint.2017.12.002. https://www.ncbi.nlm.nih.gov/pubmed/29217416.

1. Longley RJ, White MT, Takashima E, Morita M, Kanoi BN, Li Wai Suen CSN, et al. Naturally acquired antibody responses to more than 300 Plasmodium vivax proteins in three geographic regions. PLoS Negl Trop Dis. 2017;11 9:e0005888; doi: 10.1371/journal.pntd.0005888. https://www.ncbi.nlm.nih.gov/pubmed/28892517.

1. Kanoi BN, Takashima E, Morita M, White MT, Palacpac NM, Ntege EH, et al. Antibody profiles to wheat germ cell-free system synthesized Plasmodium falciparum proteins correlate with protection from symptomatic malaria in Uganda. Vaccine. 2017;35 6:873-81; doi: 10.1016/j.vaccine.2017.01.001. https://www.ncbi.nlm.nih.gov/pubmed/28089547.

1. Yagi M, Palacpac NM, Ito K, Oishi Y, Itagaki S, Balikagala B, et al. Antibody titres and boosting after natural malaria infection in BK-SE36 vaccine responders during a follow-up study in Uganda. Sci Rep. 2016;6:34363; doi: 10.1038/srep34363. https://www.ncbi.nlm.nih.gov/pubmed/27703240.

1. Palacpac NM, Ntege E, Balikagala B, Yeka A, Shirai H, Suzuki N, et al. Hematological and biochemical data obtained in rural northern Uganda. Int J Environ Res Public Health. 2014;11 5:4870-85; doi: 10.3390/ijerph110504870. https://www.ncbi.nlm.nih.gov/pubmed/24806194.

1. Palacpac NM, Ntege E, Yeka A, Balikagala B, Suzuki N, Shirai H, et al. Phase 1b randomized trial and follow-up study in Uganda of the blood-stage malaria vaccine candidate BK-SE36. PLoS One. 2013;8 5:e64073; doi: 10.1371/journal.pone.0064073. https://www.ncbi.nlm.nih.gov/pubmed/23724021.

1. Proietti C, Verra F, Bretscher MT, Stone W, Kanoi BN, Balikagala B, et al. Influence of infection on malaria-specific antibody dynamics in a cohort exposed to intense malaria transmission in northern Uganda. Parasite Immunol. 2013;35 5-6:164-73; doi: 10.1111/pim.12031. https://www.ncbi.nlm.nih.gov/pubmed/23473542.

1. Proietti C, Pettinato DD, Kanoi BN, Ntege E, Crisanti A, Riley EM, et al. Continuing intense malaria transmission in northern Uganda. Am J Trop Med Hyg. 2011;84 5:830-7; doi: 10.4269/ajtmh.2011.10-0498. https://www.ncbi.nlm.nih.gov/pubmed/21540398.

1. Corran P, Drakeley C, Proietti C, Tetteh K, Riley E, Kanoi BN, Ntege EH, Egwang T, Baldracchini F, Gray J, Pettinato D, Low W, Martin C, Wolff F, Rousselle T, Failly M, Dottorini T, Mazzoleni G, Crisanti A. 2009, Fightmal: Correlating protection against malaria with serum profiles against multiple P. falciparum antigens. Trop Med Int Health, 14: 125-125

1. Kanoi B, Agwang C, Egwang T. 2008. Management of swallowing problems (oesophageal disorders) in people with HIV. HIV and AIDS Treat. in Pract. (HATiP) 119: 1-12

1. Kanoi BN, Egwang TG. New concepts in vaccine development in malaria. Curr Opin Infect Dis. 2007;20 3:311-6; doi: 10.1097/QCO.0b013e32816b5cc2. https://www.ncbi.nlm.nih.gov/pubmed/17471043.

1. Kanoi B, Mujuzi G, Ogwal A, Okech B, Egwang TG. Pigmented white blood cell number as a negative correlate of clinical immunity in Ugandan children with severe complicated or uncomplicated malaria. Acta Tropica 95S: S1-S506 (55A)

1. Kanoi B, Magambo B, Okech B, Egwang TG. Differential Serum expression of the CC-chemokine MCP-1, MIP-3a and RANTES in Uganda Infants with severe or uncomplicated malaria. Acta Tropica 95S: S1-S506 (296B).